Gary Caldwell could be ruled out of football until the new year after aggravating a thigh injury.
The news comes in the same week that his former Celtic team-mate Stephen McManus underwent an ankle operation that will rule the former Celtic skipper out of action until March.
Caldwell recently returned to the Wigan team after an end of season hip operation but after being substituted during their 1-0 win over West Brom the defender is facing another lengthy spell on the sidelines.
Wigan boss Roberto Martinez said: “It’s a tear in his quadriceps and we’re still assessing the extent of the injury but with these injuries you always fear the worse which could rule him out between 4-6 weeks.
“Hopefully though it will reveal to be a small tear and Gary could be back playing sooner, but we’ll find out over the next week.
“It’s a big shame for Gary because you could see that game-by-game he was adding to his game. His mobility has been good, he’s a leader on the pitch and has been reading games very well.”
Caldwell joined Wigan in January from Celtic for £1m after turning down the chance to join former manager Gordon Strachan at Middlesbrough.