Callum McGregor and Kieran Tierney come into the side but there is no place for James Forrest with Clarke giving a first competitive cap to Billy Gilmour in a much changed team. Lyndon Dykes retains his place with Che Adams joining him in attack.
Clarke seems to have been stung by the criticism that his selection attracted at Hampden on Monday but moving Scott McTominay into defence with McGregor and Gilmour starting is more drastic than many predicted.
Scotland really need to take a point from the match to maintain a realistic chance of qualifying.
With Croatia drawing at Hampden against the Czech Republic Scotland go into tonight’s match pointless, if that remains the case at the final whistle not even a win on Tuesday against Croatia would guarantee a place in the last sixteen among the four best third placed teams.
SCOTLAND: Marshall: O’Donnell, McTominay, Hanley, Tierney, Robertson; Gilmour, McGinn, McGregor; Adams, Dykes
SUBS: Gordon, McLaughlin, Christie, Fleck, Cooper, Armstrong, Nisbet, Fraser, Patterson, Hendry, Forrest, McKenna